Home > Life Science Research > DMPK Services
DMPK Services

Preclinical DMPK studies are designed to investigate the absorption, distribution, metabolism and excretion of new chemical entities / Natural products to support drug discovery program in the

lead identification and lead optimization phase.

G7 SYNERGON offers a wide range of In-Vitro and In-Vivo DMPK services:

In-vitro DMPK services

•  Aqueous solubility and stability of the compounds at different pH
•  Log P and Log D estimation
•  Short term and long term stability of the compound in various biological matrices
•  Metabolic stability studies using cellular, sub cellular fractions and various recombinant CYP isoforms such as CYP3A4, CYP2C9, CYP2C19, CYP2D6 and CYP1A2
•  Drug - Drug interaction studies by CYP450 inhibition and induction assays
•  Cell permeability assays using PAMPA, MDCK and CaCo-2
•  Plasma/serum protein binding by ultrafiltration / equilibrium dialysis technique


In-Vivo DMPK services

•  Absolute Bioavailability studies
•  Single, Multiple and cassette dosing
•  Ascending dose PK studies in rodents
•  PK studies in cannulated and non cannulated rodents




“G7 SYNERGON has been recognized by the Department of Scientific and Industrial Research (D...


India, an emerging global hub for vaccine industry ASIA is emerging as the vaccine hub ...

Post Marketing Clinical (PMC)

Phase IV Studies – A Market With A Proactive Approach For Growth Of A Pharmaceutical Busine...

Vaccine Industry in India – An Emerging Global Hub

Asia is emerging as the vaccine hub of the world and India is on the go to play a key role in the...
Counter :mod_vvisit_countermod_vvisit_countermod_vvisit_countermod_vvisit_countermod_vvisit_countermod_vvisit_counter

© 2019 G7 SYNERGON. All rights Reserved