Preclinical DMPK studies are designed to investigate the absorption, distribution, metabolism and excretion of new chemical entities / Natural products to support drug discovery program in the

lead identification and lead optimization phase.

G7 SYNERGON offers a wide range of In-Vitro and In-Vivo DMPK services:

In-vitro DMPK services

•  Aqueous solubility and stability of the compounds at different pH
•  Log P and Log D estimation
•  Short term and long term stability of the compound in various biological matrices
•  Metabolic stability studies using cellular, sub cellular fractions and various recombinant CYP isoforms such as CYP3A4, CYP2C9, CYP2C19, CYP2D6 and CYP1A2
•  Drug - Drug interaction studies by CYP450 inhibition and induction assays
•  Cell permeability assays using PAMPA, MDCK and CaCo-2
•  Plasma/serum protein binding by ultrafiltration / equilibrium dialysis technique

In-Vivo DMPK services

•  Absolute Bioavailability studies
•  Single, Multiple and cassette dosing
•  Ascending dose PK studies in rodents
•  PK studies in cannulated and non cannulated rodents